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are allergic to sildenafil, as contained in VIAGRA and Revatio®, or any in the elements in VIAGRAOutcomes of Other Medications on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (key route) and CYP2C9 (minor route). Consequently, inhibitors of those isoenzymes may perhaps lower sildenafil clearance and inducers of those isoenzymes c